Insert pdf file content into a powerpoint presentation powerpoint. How to insert a pdf into powerpoint online tech tips. Do not inject directly into the circulatory system. Biofac thrombin can be used for measuring the thrombin clotting time. Remove flipoff cap from the top of the recothrom vial. May 22, 2019 insert the nasal drug delivery device into the naris and spray the thrombinjmi thrombin solution onto the nasal mucosa through the nasal drug delivery device by depressing the syringe plunger using mild or moderate pressure on the syringe plunger.
Clinical use of topical thrombin as a surgical hemostat. Tell all of your health care providers that you take thrombin jmi thrombin. Achieving hemostasis is a crucial focus of clinicians working in surgical and trauma settings. Recothrom, thrombogen thrombin dosing, indications. Do not reexpose patients to thrombinjmi if there are known or suspected antibodies to bovine thrombin andor factor v. Argatroban does not interact with heparininduced antibodies. Bovine thrombin is an enzyme that activates factor xiii and converts fibrogen into fibrin. Oct 15, 2010 the therapeutic use of thrombin has an extensive history, with bovine thrombin first clinically used by surgeons in world war ii and the korean war. Must not be injected or otherwise allowed to enter large blood vessels. If you think there has been an overdose, call your poison control center or get medical care right away.
Insert the nasal drug delivery device into the naris and spray the thrombinjmi. Id like to introduce into my expression vector a thrombin cleavage site. The standalone thrombin products thrombin jmi are packaged as a powder that is reconstituted for use. The number of thrombin jmi treated patients with antibovine antibodies at 48 hours postsurgery was less than that seen presurgery but was increased at 4 and 8 weeks from 48 hours. Recothrom, thrombin topical recombinant package insert. Because of its action in the clotting mechanism, thrombinjmi can cause extensive intravascular clotting or death. Thrombin is a naturally occurring enzyme that converts fibrinogen into fibrin, which is an integral step in clot formation. Depending on the source of the sample and the analytical application, dissolve the contents of each vial with. Open powerpoint and create a new presentation or open an existing ppt file. Apply powder thrombinjmi directly to the bleeding area or on oozing surfaces may soak in up to 10 ml of absorbable gelatin sponge evithrom applied on bleeding surface wet product with up to 3 ml, 10 ml, or 20 ml of thrombigel 10, 40, 100, respectively, of 0. The b chain of bovine thrombin includes a carbohydrate portion of mw 2.
It is ideal for presenting data contained within other. Make sure of the complete reconstitution of the product. Safety and efficacy of topical thrombin human grifols as an. Topical hemostatic agents play an important role in both common and. Thrombinjmi may also be used with floseal nt according to the directions for use in the floseal nt package insert. Pdf clinical use of topical thrombin as a surgical hemostat. Adult men and women who are scheduled to undergo qualified surgeries defined as surgeries likely to require the use of an active topical hemostatic agent, but not likely to require transfusion of plasma, and who complete the informed consent process, and who meet all of. Postoperative hemorrhage control is managed in several ways, and more than one method may be used to achieve hemostasis. Use thrombinjmi thrombin solution syringe according to the directions for use in the gelflow nt package insert.
This openlabel study assessed the impact on clinical hemostasis of human antibodies to bovine thrombin abt or factor vva abvva in response to topical bovine thrombin thrombinjmi in patients both with and without preexisting antibovine antibodies. Therefore its primary use is in the defibrination of plasma to produce serum matrixes to be used as controls and standards. Jmi is a registered trademark of king pharmaceuticals, inc, bristol. Thrombinjmi thrombin, topical, bovine origin this product information is intended only for residents of the united states. The quality of the pdf file is reduced with this method, but you can open the full pdf file by doubleclicking the image when viewing or editing in normal view. Thrombin, in turn, catalyzes the conversion of fibrinogen factor ia soluble plasma protein into long, sticky threads of insoluble fibrin factor ia. Evithrom is packaged as a solution, and stored in a freezer. Affix the nasal drug delivery device on to the syringe by pushing the device down onto the thrombinjmi thrombin solution filled syringe and turn clockwise until the nasal drug delivery device locks in place. Thrombin, topical bovine, a plasma derivative labeled by pfizer laboratories div. While thrombin recognizes leuvalproargglyser i wonder whether i need. Inject the saline diluent into the thrombinjmi thrombin vial from the syringe to reconstitute the thrombinjmi thrombin powder. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and.
Observational study assessing the impact of exposure to. The pdf file should be the first option within the insert dialog window. Safety and efficacy of topical thrombin human grifols as. Postoperative hemorrhage control is managed in several ways, and more.
Thrombin jmi thrombin, bovine is used to help surgeons stop bleeding that occurs during surgery. Thrombin from bovine plasma t75 product description. Adult men and women who are scheduled to undergo qualified surgeries defined as surgeries likely to require the use of an active topical hemostatic agent, but not likely to require transfusion of plasma, and who complete the informed consent process, and who meet all of the inclusion. Owing to thrombins role at the end of the coagulation cascade. Open the ppt and go on the slide that you want to insert a pdf into. The ndc code 6079321505 is assigned to thrombinjmi also known as. The b chain of human thrombin consists of a peptide portion. Extensive intravascular clotting and even death may result. Thrombin has a number of wellstudied biological activities, which serve to achieve coagulation and hemostasis. Be ready to tell or show what was taken, how much, and.
Thrombin is the main enzyme of the coagulation pathway with multiple key activities. Bovine thrombin from rmbio is produced as a lyophilized powder that is activated from highly purified prothrombin. Hemosil thrombin time 0009758515 english insert revision. Topical hemostatic agentsincluding mechanical hemostats, active hemostats, flowable hemostats, and fibrin sealantsare frequently used in efforts to control bleeding, and new options such as hemostatic dressings, initially used in combat situations, are increasingly being used in civilian. Tct is a blood test that measures the time it takes for a clot to form in the plasma of a blood sample containing anticoagulant, after an excess of thrombin has been added. Ppt thrombin generation assays powerpoint presentation. Schreiber md, in consultative hemostasis and thrombosis third edition, 20. Due to its factor sensitivity it can be used to assay the activity of coagulation factors in the extrinsic and common pathway of coagulation factors ii, v, vii, and x. Inserting a pdf as an image is a quick way to present flat data in a noninteractive fashion. However, the primary function of thrombin is to cleave fibrinopeptides fp a and b from the. This includes your doctors, nurses, pharmacists, and dentists. Immune responses associated with perioperative exposure and.
Insert pdf file content into a powerpoint presentation. Tell your doctor if you are pregnant, plan on getting pregnant, or are breastfeeding. Thrombin definition of thrombin by medical dictionary. Accidental injection of topical thrombin continues. Mar 02, 2018 thrombinjmi may also be used with floseal nt according to the directions for use in the floseal nt package insert. You will need to talk about the benefits and risks to you and the baby. Adding thrombin for additional hemostasis does not affect the action of. Because its a special case i can not use a ready to use plasmid where a thrombin cleavage site already exists. Hemostat thromboplastin liquid is a highly sensitive reagent intended for the manual and automated determination of prothrombin time pt in liquid format. Thrombin causes vasoconstriction on smooth muscle cells. Open powerpoint and display the slide where you want to insert the pdf text. This accredited monograph is available in pdf format.
The thrombin can be drawn into sterile syringes as smaller aliquots i. Oct 28, 2011 bovine thrombin is the most common and least expensive of the active hemostats used in the united states today. Thrombinjmi fda prescribing information, side effects. The cumulative average dose of thrombin reported in the literature is approximately 1100 u per patient. Recothrom, thrombin topical recombinant, is a topical thrombin indicated o aid t hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is. To achieve hemostasis, one floseal matrix hemostatic sealant kit fusion medical. When the thrombinjmi powder is completely dissolved, draw the thrombinjmi thrombin solution into the syringe.
In addition to the coagulation cascade, thrombin act directly on a number of cell types, e. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. It is thought that impurities in bovine thrombin preparations are responsible for the. The therapeutic use of thrombin has an extensive history, with bovine thrombin first clinically used by surgeons in world war ii and the korean war. The fibrin threads form a mesh that traps platelets, blood cells, and plasma. Topical bovine thrombin has been associated with immune responses and anecdotal reports of coagulopathy. Thrombinjmi thrombin, bovine is used to help surgeons stop bleeding that occurs during surgery. Thrombinjmi can be used in a dry form on oozing surfaces. Diluted buffer thrombin concentration screening test 5. Lowdose thrombin injection to treat iatrogenic femoral. Thrombinjmi and recothrom are stored at room temperature, as a powder, which is reconstituted with saline into solution for use. The number of thrombin jmi treated patients with ahvva and aht antibodies similarly increased at 4 and 8 weeks compared with 48 hours data not shown. Oct 20, 2008 this study is intended to observe the effects of possible repeat exposure to topical thrombinjmi on aptt.
In instances where a concentration of approximately 1,000 unitsml is desired, the contents of the vial of sterile isotonic saline diluent may be transferred into the thrombinjmi container with a sterile syringe or sterile transfer device. In the last decade, the number of different topical hemostatic agents has. Find patient medical information for thrombinjmi topical on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Apply powder thrombin jmi directly to the bleeding area or on oozing surfaces may soak in up to 10 ml of absorbable gelatin sponge evithrom applied on bleeding surface wet product with up to 3 ml, 10 ml, or 20 ml of thrombigel 10, 40, 100, respectively, of 0. Implementing methods to improve perioperative hemostasis. Prothrombin coagulation factor ii is proteolytically cleaved to form thrombin in the clotting process.
Remove the syringe from the transfer device by turning syringe counterclockwise. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. In the insert object box, select create from file, and then enter the pdf file location. Thrombin topical bovine originthrombin jmi generic is hematologic agent, prescribed for hemostasis and for temporary control of moderately to severely bleeding wounds. Due to its factor sensitivity it can be used to assay the activity of coagulation factors in the extrinsic and common pathway of. Early bovine thrombin formulations have been conclusively linked to the development of antibodies that crossreact with multiple human coagulation proteins, factor v being the most important. Thrombin injection ultrasound guided compression surgical repair. Bovine thrombin is composed of a light chain a chain, mw 5 kda and a heavy chain b chain, mw 33 kda. Antithrombin recombinant us package insert atryn for injection february 3, 2009 highlights of prescribing information. Dec 18, 20 this was a prospective, randomized, doubleblind, controlled, phase ii study to evaluate the safety and efficacy of topical thrombin human grifols as an adjunct to hemostasis during vascular ig1202a, hepatic ig1202b, soft tissue ig1202c, and spinal ig1202d surgical procedures.
Attach the needlefree transfer device and snap it into place on the vial by placing the vial on. Implementing methods to improve perioperative hemostasis in. Thrombin has had a long history in surgical hemostasis, and has proven to be a useful and effective ancillary for surgical hemostasis. Topical thrombin, evithrom, recothrom, thrombinjmi, converts fibrinogen into fibrin. For use with gelflow nt, reconstitute thrombinjmi 5,000 iu powder with 5 ml sterile isotonic saline and use thrombinjmi thrombin solution according to the directions for use in the gelflow nt package insert. Thrombin, topical bovine, a plasma derivative labeled by pfizer laboratories div pfizer inc. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Immune responses associated with perioperative exposure. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Thrombinjmi information, side effects, warnings and recalls.
The use of topical hemostatic agents in cardiothoracic surgery. Mar 19, 2020 when the thrombinjmi powder is completely dissolved, draw the thrombinjmi thrombin solution into the syringe. In late 2016, chpso, one of the largest federally designated patient safety organizations, created in 2008 by the california hospital association, published a case report about accidental intravenous iv administration of recothrom recombinant topical thrombin. Antithrombin recombinant us package insert atryn for injection february 3, 2009 these highlights do not include all the information needed to use atryn safely. Thrombinjmi thrombin, topical usp, bovine origin package insert. Argatroban is capable of inhibiting the action of both free and clotassociated thrombin. If you have any questions about thrombinjmi thrombin, please talk with your doctor, nurse, pharmacist, or other health care provider. Alternatively, flood surfaces with thrombin solution using a sterile syringe and small gauge needle.
Therefore, care should be taken when using this product. After cardiovascular suric aln terv o s, bmd occurs in 3% to 14% of cases. Thrombin is available as a standalone product and is also a component of other biologic hemostatic agents. Like the other local hemostats combined, it is an expensive product, and its. Topical hemostatic agents and their role in upper extremity surgery. In vivo thrombin is formed from prothrombin as a result of activation of both the intrinsic and extrinsic pathways of the coagulation cascade. Insert pdf content into your presentation either as a picture that shows on your slide, or as a document that you can open during your slide show. Thrombin is a coagulant drug that works by encouraging your blood to clot.
Crossreactivity of various thrombin products with anti. In instances where a concentration of approximately 1,000 units per ml is desired, the contents of the vial of sterile isotonic saline diluent may be transferred into the thrombinjmi container with a sterile syringe or sterile transfer device. This was a prospective, randomized, doubleblind, controlled, phase ii study to evaluate the safety and efficacy of topical thrombin human grifols as an adjunct to hemostasis during vascular ig1202a, hepatic ig1202b, soft tissue ig1202c, and spinal ig1202d surgical procedures. Thrombinjmi fda prescribing information, side effects and uses. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Treatment of iatrogenic femoral artery pseudoaneurysms with thrombin injection has been reported as an efficacious and safe procedure. In addition, to explore the possibility of crossreactivity of rabbit antirecothrom igg, antievithrom igg, and antijmi thrombin igg with human thrombin as well as other topical thrombin, we have used single amount of 0. To insert a pdf into powerpoint without losing quality, follow the steps below. Click the image and it will be inserted into the slide. To insert the pdf as an object in powerpoint, make sure the pdf file isnt open on your computer, and then go to the powerpoint slide where. Excessive bleeding complicates surgery and may result in a higher risk of. Thrombinjmi thrombin bovine origin dose, indications.
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